SMAD2(Ser465) Antibody

Basic information

Name

SMAD2(Ser465) Antibody

size

0.1ml

Catalog number

bs-0457R

Price

281 €

Details & buy    

Extended information

Gene ID number

4087

Modification site(s)

Ser465

Swiss Prot

Q15796

French translation

anticorps

Subcellular location

Cytoplasm

Immunogen range

457-467/467

Concentration

1ug per 1ul

Conjugation

Unconjugated

Target Antigen

SMAD2 Ser465

Modification(s)

Phosphorylation

Cross reactivity

Human, Mouse, Rat

Also known as

SMAD2(Ser465) PAb

Category

Primary Antibodies

Clonality

Polyclonal antibody

Clone number

Polyclonal antibody

Tested Applications

WB, IHC-P, IF(IHC-P)

Long name

SMAD2(Ser465) Primary Polyclonal Antibody

Purification method

This antibody was purified via Protein A.

Recommended dilutions

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Specificity

This is a highly specific antibody against SMAD2 Ser465.

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human SMAD2 around the phosphorylation site of Ser465

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonym names

JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2

Background of the target antigen

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.