Smad7 + Smad6 Antibody

Basic information

Name

Smad7 + Smad6 Antibody

size

0.1ml

Catalog number

bs-0566R

Price

263 €

Details & buy    

Extended information

Modification(s)

None

Gene ID number

4092

Swiss Prot

O15105

Immunogen range

1-50/426

French translation

anticorps

Concentration

1ug per 1ul

Conjugation

Unconjugated

Target Antigen

Smad7 + Smad6

Cross reactivity

Human, Mouse, Rat

Also known as

Smad7 + Smad6 PAb

Category

Primary Antibodies

Subcellular location

Cytoplasm, Nucleus

Modification site(s)

Unmodified antibody

Clonality

Polyclonal antibody

Clone number

Polyclonal antibody

Tested Applications

WB, ELISA, IHC-P, IF(IHC-P)

Long name

Smad7 + Smad6 Primary Polyclonal Antibody

Purification method

This antibody was purified via Protein A.

Specificity

This is a highly specific antibody against Smad7 + Smad6.

Recommended dilutions

WB(1:100-1000), ELISA(1:500-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Smad7

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonym names

CRCS3; MADH7; MADH8; Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7

Background of the target antigen

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).