Activin A Recombinant Protein

Basic information

Name

Activin A Recombinant Protein

size

0.002 mg, 0.01 mg

Catalog number

40-212

Price

683 €

Extended information

NCBI ID

4087

Protein's origin

Human

Uniprot

Q15796

Rec. PROTEIN GI#

51173730

Vial

Lyophilized

Group

recombinants

Source

Homo sapiens

Accession nr

NP_001003652.1

Gene name

SMAD family member 2

Additional source

Recombinants or rec. proteins

Recombinant in

(BTI-Tn-5B1-4) High-5 Insect cells

About

This product is for research use only.

Other name of the recombinant

JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2

Pureity

Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).

SEQUENCE

GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

Activity

The ED50 was determined by its ability to inhibit the proliferation of murine MPC - 11 cells is ≤ 2 ng/mL, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Keep at

The lyophilized Activin A recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Activin A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Activin A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

About recombinant protein

Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, Follistatin. Human Activin A is a 26.0 kDa disulfide-linked homodimer of two β A chains, each containing 116 amino acid residues.