Smad3 Inhibitor, SIS3 for cell activation

Basic information

Name

Smad3 Inhibitor, SIS3 for cell activation

size

1 mg

Catalog number

2227-1

Price

164 €

Extended information

Is this a salt?

No

Supplied with

N/A

Peptide sequence

N/A

Is it cell-permeable?

Yes

Tissue

cell

Storage condition

-20°C

Molecular weight

489.99

Shipping condition

gel pack

Maximum time for storage

24 months

CAS number

521984-48-5

Physical appearance

Yellow solid

Category

Biochemicals

Purification

≥98% by HPLC

Reconstitute instructions

DMSO (>20 mg/ml)

Molecular formula

C₂₈H₂₇N₃O₃ ∙ HCl

Storage instructions

Protect from light and moisture

Other name

(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

Description

A potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-β1/ALK5-induced Smad3 phosphorylation. Also inhibits the TGF-β1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site.

Additional description

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.