anti-Anti-SMAD2/3 Antibody

Basic information

Name

anti-Anti-SMAD2/3 Antibody

size

Anti-SMAD2/3 Antibody

Catalog number

A1214-100

Price

403 €

Details & buy    

Extended information

This antibody has been succesfully tested for use in following methods:

WB

Clone:

N/A

Antibody host:

Rabbit

Form of antibody:

Liquid

Shipping conditions:

gel pack

French translation

anticorps

Clonality of antibody:

Polyclonal

Isotype:

Rabbit IgG

Target of this antibody:

SMAD2/SMAD3

This antibody reacts with:

Human, Mouse, Rat

Purification method:

Affinity purified

Recommended usage:

WB; 1:500 – 1:2000

Storage information:

Shelf time: 12 months in temp.: -20 deg.C

How to handle this antibody:

The antibody solution should be gently mixed before use

Formulation of this antibody:

In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Immunogene sequence:

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SMAD2/3

Properties

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Alternative names of antibody target:

SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3

Background information:

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.