SMAD2 Polyclonal Antibody

Basic information

Name

SMAD2 Polyclonal Antibody

size

50 μg

Catalog number

CAC07043

Price

245 €

Extended information

Raised in

Rabbit

Use before

1 year

Protein number

Q15796

Shipping requirements

Blue ice

French translation

anticorps

Clonality

Polyclonal

Verified reactivity

Human, Mouse

Estimated production time

3-7 business days

NCBI number

Please refer to NCBI

Gene number

Please refer to GenBank

Purity

Protein G purified,>95%

Group

Polyclonals and antibodies

Notes

For research use only. Not for diagnostic procedures.

Storage recommendation

Aliquot and store at -20°C. Minimize freezing and thawing.

Immunogen

Recombinant human Mothers against decapentaplegic homolog 2 protein (2-467AA)

Verified applications

ELISA,WB,IHC,IF. Recommended dilution:WB:1:2000-1:5000,IHC:1:20-1:200,IF:1:50-1:200

Properties

If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Other name

Mothers against decapentaplegic homolog 2MAD homolog 2Mothers against DPP homolog 2,JV18-1,Mad-related protein 2,hMAD-2,SMAD family member 2,SMAD 2,Smad2,hSMAD2,SMAD2,MADH2,MADR2

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Supplementary information

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.