Recombinant Human SMAD Family Member 1/SMAD1 Protein(N-GST) 50µg

Basic information

Name

Recombinant Human SMAD Family Member 1/SMAD1 Protein(N-GST) 50µg

size

50µg

Catalog number

PKSH033065-50µg

Price

577 €

Details & buy    

Extended information

Activity

NA

Fusion tag

N-GST

Expressed Host

E.coli

Accession

Q15797

Mol Mass

78.7 kDa

AP Mol Mass

28&89 kDa

Sequence

Met1-Ser465

Group

recombinants

Source

Recombinants or rec. proteins

Purity

＞95% as determined by reducing SDS-PAGE.

Reconstitution

Please refer to it for detailed information.

Endotoxin

＜1.0 EU per µg as determined by LAL test.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0 .

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability and Storage

Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months

Synonym

Mothers Against Decapentaplegic Homolog 1; MAD Homolog 1; Mothers Against DPP Homolog 1; JV4-1; Mad-Related Protein 1; SMAD Family Member 1;Transforming Growth Factor-Beta-Signaling Protein 1; BSP-1; SMAD1; BSP1; MADH1;SMAD 1;Smad1;hSMAD1;MADR1

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Background

SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.