Smad3 (Ser423 + Ser425) Antibody, ALEXA FLUOR 488
100ul
bs-3425R-A488
350 €
4088
P84022
anticorps
IF(IHC-P)
Polyclonal
Alexa Fluor
1ug per 1ul
380-425/425
499nm/519nm
Ser423 + Ser425
Phosphorylation
ALEXA FLUOR® 488
Human, Mouse, Rat
Cytoplasm, Nucleus
Polyclonal antibody
IF(IHC-P)(1:50-200)
Smad3 Ser423 + Ser425
Purified by Protein A.
Conjugated Primary Antibodies
Rabbit (Oryctolagus cuniculus)
Anti-Smad3 Ser423 + Ser425 PAb ALEXA FLUOR 488
Smad3 (Ser423 + Ser425) Antibody, ALEXA FLUOR 488 Conjugated
This is a highly specific antibody against Smad3 Ser423 + Ser425.
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
KLH conjugated synthetic phosphopeptide derived from human Smad3 around the phosphorylation site of Ser423/425 [CS(p-S)V(p-S)]
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; SMAD family member 3; SMAD 3; Smad3; hSMAD3
For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Smad3 Ser423 + Ser425 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
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