SMURF1 Antibody

Basic information

Name

SMURF1 Antibody

size

0,1 mg

Catalog number

PB9892

Price

374 €

Details & buy    

Extended information

Analyses

WB

Entrez GeneID

57154

Reacts with species:

human

Target antigen

SMURF1

Raised in

rabbit

Uniprot ID

Q9HCE7

Gene Name

SMURF1

French translation

anticorps

Product form

freeze-dried

Clonality

Polyclonal antibody

Clone

Polyclonal antibody

Type of the antibody

IgG polyclonal antibody

Purification

Immunogen affinity purified.

Protein Name

E3 ubiquitin-protein ligase SMURF1

Gene Full Name

SMAD specific E3 ubiquitin protein ligase 1

Product configuration

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Solubilization

The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml

Properties

If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SMURF1 (326-351aa DHNNRTTQFTDPRLHHIMNHQCQLKE), identical to the related mouse sequence.

Tips

The SMURF1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.

Synonyms

E3 ubiquitin-protein ligase SMURF1 antibody|hSMURF1 antibody|KIAA1625 antibody|Smad specific E3 ubiquitin ligase 1 antibody|SMAD specific E3 ubiquitin protein ligase 1 antibody|Smad ubiquitination regulatory factor 1 antibody|SMAD-specific E3 ubiquitin-protein ligase 1 antibody|SMUF1_HUMAN antibody|SMURF 1 antibody|smurf1 antibody

Storage condtions

Keep the SMURF1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.

Background

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene. It is mapped to 7q22.1. This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Related articles

1. "Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1". 2. Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. 3. Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH (Sep 1999). "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation". Nature 400 (6745): 687–93.