Reacts with species:
Gene Full Name
SMAD family member 3
Type of the antibody
IgG polyclonal antibody
Immunogen affinity purified.
Mothers against decapentaplegic homolog 3
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
A synthetic peptide corresponding to a sequence in the middle region of human Smad3 (193-222aa DHQMNHSMDAGSPNLSPNPMSPAHNNLDLQ), identical to the related mouse and rat sequences.
The Smad3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
1. "Entrez Gene: SMAD3 SMAD family member 3". 2. Moustakas A, Souchelnytskyi S, Heldin CH (2001). "Smad regulation in TGF-beta signal transduction". J. Cell. Sci. 114 (Pt 24): 4359–69. 3. Zhang Y, Feng X, We R, Derynck R (September 1996). "Receptor-associated Mad homologues synergize as effectors of the TGF-beta response". Nature 383 (6596): 168–72.
Keep the Smad3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins. It is located in 15q22.33. And it mediates the signals from the transforming growth factor beta (TGF-β) super family ligands that regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.
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