SMAD6 Antibody

Basic information

Name

SMAD6 Antibody

size

0,1 mg

Catalog number

PA2134

Price

320 €

Details & buy    

Extended information

Analyses

WB

Target antigen

SMAD6

Gene Name

SMAD6

Raised in

rabbit

Uniprot ID

O43541

French translation

anticorps

Product form

freeze-dried

Clone

Polyclonal antibody

Clonality

Polyclonal antibody

Gene Full Name

SMAD family member 6

Type of the antibody

IgG polyclonal antibody

Purification

Immunogen affinity purified.

Reacts with species:

human, rat Predicted to work with: mouse

Protein Name

Mothers against decapentaplegic homolog 6

Product configuration

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SMAD6(436-452aa IKVFDFERSGLQHAPEP).

Solubilization

The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml

Properties

If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Tips

The SMAD6 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.

Storage condtions

Keep the SMAD6 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.

Synonyms

hSMAD6 antibody|HsT17432 antibody|MAD(mothers against decapentaplegic Drosophila) homolog 6 antibody|MAD homolog 6 antibody|MAD mothers against decapentaplegic homolog 6(Drosophila) antibody|MADH6 antibody|MADH7 antibody|Mothers against decapentaplegic drosophila homolog of 6 antibody|Mothers against decapentaplegic homolog 6 antibody|Mothers against DPP homolog 6 antibody|SMAD 6 antibody|SMAD family member 6 antibody|SMAD mothers against DPP homolog 6 antibody|Smad6 antibody|SMAD6_HUMAN antibody

Background

Mothers against decapentaplegic homolog 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. It belongs to the SMAD family of proteins, which belongs to the TGFbeta superfamily of modulators. By PCR screening of a somatic cell hybrid panel and YACs, this gene was mapped to 15q22.31. This gene acts as a mediator of TGF-beta and BMP antiflammatory activity. It can suppress 1L 1R-TLR signaling through its direct interaction with PEL1 and prevent NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. SMAD6 may play a role in blocking the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding and binding to regulatory elements in target promoter regions.

Related articles

1. Galvin, K. M., Donovan, M. J., Lynch, C. A., Meyer, R. I., Paul, R. J., Lorenz, J. N., Fairchild-Huntress, V., Dixon, K. L., Dunmore, J. H., Gimbrone, M. A., Jr., Falb, D., Huszar, D. A role for SMAD6 in development and homeostasis of the cardiovascular system. Nature Genet. 24: 171-174, 2000. 2. Tan, H. L., Glen, E., Topf, A., Hall, D., O'Sullivan, J. J., Sneddon, L., Wren, C., Avery, P., Lewis, R. J., ten Dijke, P., Arthur, H. M., Goodship, J. A., Keavney, B. D.Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. Hum. Mutat. 33: 720-727, 2012. 3. Topper, J. N., Cai, J., Qiu, Y., Anderson, K. R., Xu, Y.-Y., Deeds, J. D., Feeley, R., Gimeno, C. J., Woolf, E. A., Tayber, O., Mays, G. G., Sampson, B. A., Schoen, F. J., Gimbrone, M. A., Jr., Falb, D. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Nat. Acad. Sci. 94: 9314-9319, 1997.