SMAD5 Antibody

Basic information

Name

SMAD5 Antibody

size

0,1 mg

Catalog number

PA2115

Price

320 €

Details & buy    

Extended information

Target antigen

SMAD5

Reacts with species:

human

Gene Name

SMAD5

Raised in

rabbit

Uniprot ID

Q99717

Analyses

WB,IHC-P

French translation

anticorps

Product form

freeze-dried

Clonality

Polyclonal antibody

Clone

Polyclonal antibody

Gene Full Name

SMAD family member 5

Type of the antibody

IgG polyclonal antibody

Purification

Immunogen affinity purified.

Protein Name

Mothers against decapentaplegic homolog 5

Product configuration

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Solubilization

The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml

Properties

If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Tips

The SMAD5 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SMAD5(248-267aa IPQIMPSISSRDVQPVAYEE), identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Storage condtions

Keep the SMAD5 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.

Background

Mother against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SAMD5 gene. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. The gene was assigned to human chromosome 5q31. Like many other TGFbeta family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins(BMP's). It may play a role in the pathway where TGFbeta is an inhibitor of hematopoietic progenitor cells.

Synonyms

DKFZp781C1895 antibody|DKFZp781O1323 antibody|Dwfc antibody|hSmad 5 antibody|hSmad5 antibody|JV5 1 antibody|JV5-1 antibody|MAD homolog 5 antibody|MAD mothers against decapentaplegic homolog 5 antibody|MAD, mothers against decapentaplegic homolog 5 antibody|MADH 5 antibody|MADH5 antibody|Mothers against decapentaplegic homolog 5 antibody|Mothers against DPP homolog 5 antibody|MusMLP antibody|SMA and MAD related protein 5 antibody|SMAD 5 antibody|SMAD family member 5 antibody|SMAD mothers against DPP homolog 5 antibody|Smad5 antibody|SMAD5_HUMAN antibody

Related articles

1. Bruno, E., Horrigan, S. K., Van Den Berg, D., Rozler, E., Fitting, P. R., Moss, S. T., Westbrook, C., Hoffman, R. The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-beta on human hematopoiesis. Blood 91: 1917-1923, 1998. 2. Davis, B. N., Hilyard, A. C., Lagna, G., Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454: 56-61, 2008. 3. Gemma, A., Hagiwara, K., Vincent, F., Ke, Y., Hancock, A. R., Nagashima, M., Bennett, W. P., Harris, C. C. hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors. Oncogene 16: 951-956, 1998. 4. Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Kern, S. E., Hamilton, S. R., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., Vogelstein, B. Mad-related genes in the human. Nature Genet. 13: 347-349, 1996.