Smad4 Antibody

Basic information

Name

Smad4 Antibody

size

0,1 mg

Catalog number

PA1953

Price

320 €

Details & buy    

Extended information

Target antigen

Smad4

Gene Name

SMAD4

Raised in

rabbit

Uniprot ID

Q13485

Analyses

WB,IHC-P

French translation

anticorps

Reacts with species:

mouse, rat

Product form

freeze-dried

Clone

Polyclonal antibody

Clonality

Polyclonal antibody

Gene Full Name

SMAD family member 4

Type of the antibody

IgG polyclonal antibody

Purification

Immunogen affinity purified.

Protein Name

Mothers against decapentaplegic homolog 4

Product configuration

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Solubilization

The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml

Properties

If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Smad4(97-113aa RLWRWPDLHKNELKHVK), identical to the related rat and mouse sequences.

Tips

The Smad4 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.

Storage condtions

Keep the Smad4 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.

Synonyms

(Small)Mothers Against Decapentaplegic antibody|Deleted in Pancreatic Carcinoma antibody|Deleted in pancreatic carcinoma locus 4 antibody|Deletion target in pancreatic carcinoma 4 antibody|DPC 4 antibody|DPC4 antibody|hSMAD4 antibody|JIP antibody|MAD homolog 4 antibody|MAD mothers against decapentaplegic Drosophila homolog 4 antibody|MAD mothers against decapentaplegic homolog 4 antibody|MADH 4 antibody|MADH4 antibody|Med antibody|Medea antibody|Mothers against decapentaplegic homolog 4 antibody|Mothers against DPP homolog 4 antibody|OTTHUMP00000163548 antibody|SMAD 4 antibody|SMAD family member 4 antibody|SMAD mothers against DPP homolog 4 antibody|Smad4 antibody|SMAD4_HUMAN antibody

Related articles

1. Hoehe, M. R.; Berrettini, W. H.; Lentes, K.-U.:Dra I identifies a two allele DNA polymorphism in the human alpha-2-adrenergic receptor gene (ADRAR), using a 5.5 kb probe (p ADRAR). Nucleic Acids Res. 16: 9070 only, 1988. 2. Yang-Feng, T. L.; Kobilka, B. K.; Caron, M. G.; Lefkowitz, R. J.; Francke, U.:Chromosomal assignment of genes for an alpha-adrenergic receptor (ADRAR) and for another member of this receptor family coupled to guanine nucleotide regulatory proteins (RG21). (Abstract) Cytogenet. Cell Genet. 46: 722-723, 1987. 3. Hein, L.; Altman, J. D.; Kobilka, B. K. :Two functionally distinct alpha-2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402: 181-184, 1999.

Background

SMAD4(Mothers Against Decapentaplegic Drosophila Homolog of 4), also known as MADH4 or DPC4, is a protein that in humans is encoded by the SMAD4 gene. It belongs to the Darfwin family of proteins that modulate members of the TGFbeta protein superfamily. Hahn et al.(1996) identified the SMAD4 gene on chromosome 18q21.1. Howe et al.(1998) identified the SMAD4 gene within a region on 18q21.1 defined by linkage analysis in a kindred with juvenile polyposis syndrome. To test directly the hypothesis that the SMAD4 gene is a tumor suppressor that is critical for transmitting signals from transforming growth factor-beta and related ligands. SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes.