Smad1/5 (Ser463 + Ser465) Antibody

Basic information


Smad1/5 (Ser463 + Ser465) Antibody



Catalog number



281 €

Extended information

French translation


Gene ID number

4086, 4090


1ug per 1ul

Immunogen range






Modification site(s)

Ser463 + Ser465

Cross reactivity

Human, Mouse, Rat


Primary Antibodies

Subcellular location

Cytoplasm, Nucleus

Clone number

Polyclonal antibody


Polyclonal antibody

Tested Applications


Target Antigen

Smad1/5 Ser463 + Ser465

Also known as

Smad1/5 (Ser463 + Ser465) Antibody

Long name

Smad1/5 (Ser463 + Ser465) Antibody

Purification method

This antibody was purified via Protein A.

Recommended dilutions

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.


KLH conjugated synthetic phosphopeptide derived from human Smad1/5 around the phosphorylation site of Ser463/465

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.


If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.


This is a highly specific antibody against Smad1/5 Ser463 + Ser465. This phosphorylation site is homologous in the listed cross reactive species at the specified location.

Synonym names

Smad1 phospho S463/465; Smad1 phospho Ser463/465; p-Smad1 Ser463/465; Mothers against decapentaplegic homolog 1; BSP 1; BSP1; BSP-1; Dwarfin A; DwfA; hSMAD 1; hSMAD1; JV 41; JV4 1; JV4-1; JV41; MAD mothers against decapentaplegic homolog 1; Mad related protein 1; MADH 1; MADH1; Madr 1; MADR1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; Sma and Mad related protein 1; SMAD 1; SMAD-1; SMAD family member 1; SMAD mothers against DPP homolog 1 Drosophila; Spinal muscular atrophy distal with upper limb predominance; TGF beta signaling protein 1; Transforming growth factor beta signaling protein 1; SMAD1_HUMAN; MAD homolog 1; Mothers against DPP homolog 1; Mad-related protein 1; SMAD family member 1; Smad1; Transforming growth factor-beta-signaling protein 1.

Background of the target antigen

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].