Smad2 (7A5) Monoclonal Antibody

Basic information

Name

Smad2 (7A5) Monoclonal Antibody

size

0.1ml

Catalog number

bsm-50316M

Price

362 €

Extended information

Clone number

7A5

Gene ID number

4087

Modification(s)

None

Target Antigen

Smad2

Swiss Prot

Q15796

Tested Applications

WB, IP

French translation

anticorps

Clonality

Monoclonal

Concentration

1ug per 1ul

Conjugation

Unconjugated

Cross reactivity

Human, Mouse, Rat

Category

Primary Antibodies

Modification site(s)

Unmodified antibody

Purification method

Purified by Protein G.

Recommended dilutions

WB (0.1 ug/mL) IP (2.0 ug)

Long name

Smad2 (7A5) Monoclonal Antibody

Also known as

Smad2 (7A5) Monoclonal Antibody

Specificity

This is a highly specific antibody against Smad2.

Source

Recombinant human protein purified from E.coli (His-Smad2)

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonym names

JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

Background of the target antigen

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.