anti-SMAD2 Antibody

Basic information

Name

anti-SMAD2 Antibody

size

0.05 mg

Catalog number

49-314

Price

180 €

Details & buy    

Extended information

NCBI GENE nr

4087

GENE symbol

SMAD2

Protein nr

Q15796

Ncbi nr

Q15796

Ab raised in

Rabbit

Omim nr

13633914

French translation

anticorps

Type

Polyclonal

Vial with antibody

in solution

Source

Homo sapiens

Antibodie's label

unlabelled serum

Purity

Protein G Column

Antigene name

SMAD family member 2

Suspention, pH, azide

PBS, 0.05% BSA, 0.05% sodium azide

Immuno application

Western Blot, immuno-histo-chemistry

Antigen

SMAD2 antibody was made against amino acids 234 - 249 of SMAD2 (Human).

Works with

Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat

Antibody advice

SMAD2 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 ug/mL.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Keep at

SMAD2 antibody can be stored short term 4 grades C. For long term storage aliquot and store at -20 grades C. As with all antibodies avoid freeze/thaw cycles.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Gene names

SMAD2, HMAD-2, HSMAD2, JV18-1, Mad protein homolog smad2, MADR2, MADH2, SMAD 2, MAD homolog 2, Mad-related protein 2, JV18, Mother against DPP homolog 2, Mothers against DPP homolog 2, Sma- and Mad-related protein 2, SMAD family member 2

Gene info

SMAD2 is an intracellular protein belonging to the Dwarfin (DWA/B)/SMAD family. SMAD2 associates with SMAD4 for translocation to nucleus. It acts as an intracellular mediator of TGFbeta family of cytokines and activin type 1 receptor (ACVR1C). Hence it regulates multiple cellular processes like cell growth, proliferation, differentiation, and apoptosis and also cooperates with transcription factors to regulate expression of defined genes. Apart from playing an important role in TGFbeta1-induced CTGF expression they also act as markers of EMT in human PTECs. It also acts as an integrator of multiple signals in the regulation of NOS3 expression. It is ubiquitously expressed in most of the tissues and is responsible for colorectal, hepatocellular, lung and breast carcinomas as well as cervical cancer.