anti-SMURF1 Antibody

Basic information

Name

anti-SMURF1 Antibody

size

0.02 mg, 0.1 mg

Catalog number

7945

Price

180 €

Details & buy    

Extended information

Immunoglobulin

IgG

NCBI GENE nr

57154

Ab raised in

Rabbit

GENE symbol

SMURF1

Quantity per ml

1 mg/mL

Omim nr

31317292

French translation

anticorps

Ncbi nr

NP_065162

Type

Polyclonal

Vial with antibody

in solution

Source

homo sapiens

Antibodie's label

unlabelled serum

Works with

Human, Mouse, Rat

KDa

Predicted: 80, 83 kDa Observed: 78 kDa

Immuno application

ELISA, Western Blot, immuno-histo-chemistry

Antigene name

SMAD specific E3 ubiquitin protein ligase 1

Suspention, pH, azide

SMURF1 antibody is supplied in PBS containing 0.02% sodium azide.

Purity

SMURF1 antibody is affinity chromatography purified via peptide column.

Antigen

SMURF1 antibody was made against a 16 amino acid peptide near the amino terminus of human SMURF1.

Keep at

SMURF1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.

Gene names

SMAD specific E3 ubiquitin protein ligase 1, SMAD ubiquitination regulatory factor 1, E3 ubiquitin-protein ligase SMURF1

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Antibody advice

SMURF1 body can be used for detection of SMURF1 by Western blot at 1 - 2 ug/ml. Antibody can also be used for Immunohistochemistry starting at 5 ug/mL.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Spicific to

SMURF1 antibody is human, mouse and rat reactive. At least three isoforms of SMURF1 are known to exist this antibody will recognize all three isoforms. SMURF1 is predicted to not cross-react with SMURF2.

Gene info

SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1). SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2). SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3). SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4).