SMAD3 Polyclonal Antibody

Basic information

Name

SMAD3 Polyclonal Antibody

size

50 μg

Catalog number

CAC07020

Price

245 €

Details & buy    

Extended information

Verified reactivity

Human

Raised in

Rabbit

Use before

1 year

Protein number

P84022

Verified applications

ELISA,WB

Shipping requirements

Blue ice

French translation

anticorps

Clonality

Polyclonal

Estimated production time

3-7 business days

NCBI number

Please refer to NCBI

Gene number

Please refer to GenBank

Group

Polyclonals and antibodies

Other name

JV15-2 SMAD family member 3 SMAD3 MADH3

Notes

For research use only. Not for diagnostic procedures.

Purity

Caprylic Acid Ammonium Sulfate Precipitation Purified

Storage recommendation

Aliquot and store at -20°C. Minimize freezing and thawing.

Immunogen

Recombinant human Mothers against decapentaplegic homolog 3 protein (1-425AA)

Properties

If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Supplementary information

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.